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KMID : 0382320060260030086
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Environmental Mutagens and Carcinogens
2006 Volume.26 No. 3 p.86 ~ p.88
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Promoter Methylation and Expression of CYP1A2 in Diethylnitrosamine-induced Mice Liver Tumors
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Jin Bo-Hwan
Ryu Doug-Young
Oh Sae-Jin
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Abstract
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Cytochrome P450 1A2 (CYP1A2) is a xenobiotic metabolizing enzyme that is tissue-specifically expressed in the mammalian liver. In this study, the extent of CYP1A2 promoter methylation was analyzed to determine its potential role in the regulation of CYP1A2 in diethylnitrosamine (DEN)-induced mouse liver tumors. CYP1A2 mRNA was under-expressed about three fold in DEN-induced liver tumors compared to agematched control livers. The CYP1A2 promoter was hypermethylated in DEN-induced liver tumors compared to controls, especially in a promoter domain close to the coding region. These results suggest that promoter methylation is involved in the regulation of CYP1A2 in mouse liver tumors.
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KEYWORD
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CYP1A2, Methylation, Diethylnitrosamine, Mouse, Liver
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